Endocrine Abstracts

Objective: Metformin was considered as a weight lowering agent in diabetes patients, while it remained unclear in simple obesity patients. We aimed to investigate if metformin is effective and safe in the therapy of normoglycemic obesity.Methods: We systematically searched MEDLINE (1950–2011), EMBase (1950–2011), and CCTR (4th Issue 2011), and collected and screened all randomized controlled trials compared metformin and placebo in obese partic...